Endocrine Abstracts

Introduction: Ephrin receptors (EPHs) compose the largest known subfamily of receptors tyrosine kinases and are bound and interact with EPHs-interacting proteins (Ephrins). They have a role in tumor growth, invasion, angiogenesis and metastasis of several neoplasms. Aim of the study was to investigate the expression of EPH-A4, -A5, -B2 and -B5 in pituitary lesions. Material and Methods: Our study group consisted of 18 patients (9 males with median age 54...

Introduction: The prevalence of lymph node metastasis from micropapillary thyroid carcinoma (mPTC) in different studies is up to 33%. Preoperative diagnosis of central lymph node (CLN) metastasis is essential for the surgical management of those patients. Prophylactic CLN dissection for patients with mPTC is controversial. Our study aimed to assess the prevalence and the risk factors of LMN metastasis in patients mPTC Methods: We retrospectively study th...

Aim: To explore the metabolic phenotype of Male Obesity-associated Secondary Hypogonadism (MOSH) and following treatment with long-acting intramuscular (IM) testosterone undecanoate.Methods: A prospective observational pilot study on metabolic effects of IM testosterone undecanoate in MOSH (Hypogonadal [HG] group, n=13), including baseline comparisons with controls (Eugonadal [EG] group, n=15). Half the subj...

Aim: To explore the metabolic phenotype of Male Obesity-associated Secondary Hypogonadism (MOSH) and following treatment with long-acting intramuscular (IM) testosterone undecanoate.Methods: A prospective observational pilot study on metabolic effects of IM testosterone undecanoate in MOSH (Hypogonadal [HG] group, n=13), including baseline comparisons with controls (Eugonadal [EG] group, n=15). Half the subj...

Background: Liraglutide is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist that promotes weight loss. The minimum adequate/good response to liraglutide (≥5% weight loss at 3 months) is not achievable in all patients. Currently there are no biomarkers to predict good response. Enhanced postprandial glicentin concentration was recently considered as superior to GLP-1 in predicting weight loss following bariatric surgeries.Objective 1) T...

Objective: Glycemic control of patients with type 1 diabetes is mainly based on insulin administration. The ongoing technological developments in continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) provide new treatment strategies, with better glycemic control. This study assessed the clinical impact of two treatment strategies in adults with type 1 diabetes (T1D): multiple daily insulin injections (MDII) vs continuous subcutaneous insulin i...

Introduction: Graves’ Orbitopathy (GO), the most common extrathyroidal manifestation of Graves’ disease (GD), usually presents bilateral disease. However, a minority of patients present with unilateral disease, the prevalence of which is between 4,5% and 14%. The aim of our study is to evaluate the specific demographic and clinical characteristics and potential differences between bilateral and unilateral GO, and the association with disease activity and severity.</p...

Introduction: Hyalinizing trabecular tumors are extremely rare and uncommon thyroid tumors, which were first described by Carney et al. Until now, their preoperative diagnosis based on cytological characteristics is not possible, because of the lack of specific features and molecular markers.Case presentation: We present a 38-year-old Caucasian female, non-smoker, with a disease-free medical history, with a right-sided clearly delimited large hy...

Introduction: Hyperglycemia in type 1 diabetes mellitus (T1DM) is an important determinant of bone health. However, data on the effect of glycemic changes on bone metabolism are limited. The aim of this study was to evaluate BMD in patients with T1DM in relation to changes of glycemic control.Methods/Design: We studied 118 uncomplicated patients with T1DM (GroupD) (mean age: 30.12+8.78years, F/M: 65/53) and 94 healthy controls (GroupC) matched for age, s...

Introduction: Latent autoimmune diabetes of the adults (LADA) is a heterogeneous type of diabetes sharing clinical characteristics of type 2 DM and serum markers of pancreatic autoimmunity detected in type 1 DM. It accounts for 2-12% of all patients with diabetes. The aim of our study is to identify the association between LADA and other systemic or organ-specific autoimmune diseases.Materials and Methods: We conducted an observational study in the outpa...